PROPHYLAXIS AND CONTINUOUS-INFUSION FOR HEMOPHILIA - CAN WE AFFORD IT

Little is known about the ideal factor regimen for hemophiliacs nor ho w treatment should be administered. A prospective multicenter study ev aluated different dosage regimens and defined orthopedic outcomes, bas ed on factor consumption and a comparison of prophylaxis with on-deman d therapy. Praphylaxis led to better outcomes, whether joints were ini tially normal or previously affected. Factor use was substantially mor e costly if prophylaxis was used, but a major reduction could be achie ved if continuous infusion were feasible.