A patient who was known to have chronic myeloid leukemia (CML) in tota
l systemic remission presented with bilateral pseudohypopyon and exuda
tive retinal detachment. Anterior chamber fluid cytology revealed nume
rous lymphoblasts. Because peripheral blood and bone marrow profiles w
ere normal, a diagnosis of localized lymphoblastic crisis was establis
hed. The possibility of lymphoblastic transformation in a uveal extram
edullary hematopoietic focus is confronted by the theory of lymphoblas
tic transformation of uveal leukemic infiltrates that serve as a tumor
rest untouched by the original chemotherapy.