PHONOPHORETIC PERMEATION OF PROCAINE HYDR OCHLORIDE THROUGH CELL MONOLAYER

With the aid of permanent cultured MDCK (Madin Darby Canine Kidney) ep ithelial cell a model for investigations dealing with phonophoresis ef fects was developed. The permeation of procaine hydrochloride through cell monolayers was examined while applying therapeutical ultrasound s imultaneously. It could be shown that this permeation follows Higuchi kinetics. A comparison of the velocity factors, using a continous irra diation of 1.0 W/cm(2), shows about a 4.8fold increase. Single Ultraso und pulses, however, result in a short-time enhancement of the permeat ion. The conclusion can be drawn that extent and velocity of the perme ation of procaine hydrochloride through MDCK monolayer can be controll ed by phonophoresis.