THE LOCATION OF MZF-1 AT THE TELOMERE OF HUMAN-CHROMOSOME 19Q MAKES IT VULNERABLE TO DEGENERATION IN AGING CELLS

Authors
HOFFMAN SMG HROMAS R AMEMIYA C MOHRENWEISER HW
Citation
Smg. Hoffman et al., THE LOCATION OF MZF-1 AT THE TELOMERE OF HUMAN-CHROMOSOME 19Q MAKES IT VULNERABLE TO DEGENERATION IN AGING CELLS, Leukemia research, 20(3), 1996, pp. 281-283
Citations number
8
Categorie Soggetti
Oncology,Hematology
Journal title
Leukemia research → ACNP
ISSN journal
01452126
Volume
20
Issue
3
Year of publication
1996
Pages
281 - 283
Database
ISI
SICI code
0145-2126(1996)20:3<281:TLOMAT>2.0.ZU;2-O
Abstract
A zinc-finger gene encoding a transcription factor that regulates hema topoiesis, MZF-1, is located at the extreme end of the q arm of human chromosome 19. Several lines of evidence indicate that MZF-1 lies less than 20 kb from the subtelomeric repeat region of 19q. Telomeres are known to degenerate as cells age; disruption of MZF-1 due to telomeric degeneration may play a role in the increased incidence of leukemia i n the elderly. Copyright (C) 1996 Elsevier Science Ltd.