M. Nemeth et al., THE CELLULAR ELECTROPHYSIOLOGICAL EFFECTS OF TEDISAMIL IN HUMAN ATRIAL AND VENTRICULAR FIBERS, Cardiovascular Research, 31(2), 1996, pp. 246-248
The cellular electrophysiological effects of 1 mu M tedisamil (KC 8857
) were studied in human atrial and ventricular fibers. Conventional mi
croelectrode technique was applied to record the transmembrane action
potentials at stimulation frequency of 100 per min and 37 degrees C. T
edisamil lengthened action potential duration (APD) more in atrial tha
n in ventricular muscle fibers; prolongation of APD(90) was 28.9+/-3.3
% (n=6; p<0.05) for atrial and 13.3+/-5.2% (n=6; P<0.05) for ventricul
ar tissue. The maximal rate of depolarization was depressed slightly,
but significantly by 1 mu M tedisamil only in ventricular fibers (12.9
+/-6.5%, n=6, P<0.05). From these cellular electrophysiological data i
t is concluded that the bradycardic/antiischemic agent tedisamil posse
sses marked Class III properties not only in cardiac tissues of experi
mental animals but also those of man.