CIS (1S,3R)-1-(9-ADENYL)-3-HYDROXYCYCLOPENTANE INHIBITS THE RESPIRATORY BURST FROM POLYMORPHONUCLEAR LEUKOCYTES AND HAS IN-VIVO EFFICACY INAN ACUTE AND CHRONIC MODEL OF INFLAMMATION

Authors
BORCHERDING DR BUTLER BT LINNIK MD MEHDI S DUDLEY MW EDWARDS CK
Citation
Dr. Borcherding et al., CIS (1S,3R)-1-(9-ADENYL)-3-HYDROXYCYCLOPENTANE INHIBITS THE RESPIRATORY BURST FROM POLYMORPHONUCLEAR LEUKOCYTES AND HAS IN-VIVO EFFICACY INAN ACUTE AND CHRONIC MODEL OF INFLAMMATION, Nucleosides & nucleotides, 15(5), 1996, pp. 967-979
Citations number
39
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
15
Issue
5
Year of publication
1996
Pages
967 - 979
Database
ISI
SICI code
0732-8311(1996)15:5<967:C(ITR>2.0.ZU;2-Q
Abstract
The adenine-containing carbocyclic nucleosides (1) under bar and (2) u nder bar were synthesized in optically active form and have been shown to effectively inhibit interferon-gamma priming of Lewis (LEW/N) rat air pouch-derived PMNs. Compound (2) under bar was also shown to have in vivo activity in a LEW/N rat antigen-induced arthritis model which assesses acute and chronic inflammation.