A DIRECT APPROACH TO THE SYNTHESIS OF FAMCICLOVIR AND PENCICLOVIR

Authors
CHOUDARY BM GEEN GR KINCEY PM PARRATT MJ DALES JRM JOHNSON GP ODONNELL S TUDOR DW WOODS N
Citation
Bm. Choudary et al., A DIRECT APPROACH TO THE SYNTHESIS OF FAMCICLOVIR AND PENCICLOVIR, Nucleosides & nucleotides, 15(5), 1996, pp. 981-994
Citations number
19
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
15
Issue
5
Year of publication
1996
Pages
981 - 994
Database
ISI
SICI code
0732-8311(1996)15:5<981:ADATTS>2.0.ZU;2-D
Abstract
Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1,1,1- tricarboxylate followed by decarbethoxylation/transesterification of t he unpurified product was the key sequence in synthesising both the an ti-herpesvirus agent penciclovir and its oral form famciclovir in thre e isolated steps.