IDENTIFICATION OF BETA-HYDROXY-5-ALPHA-CHOLEST-6-ENE-5-HYDROPEROXIDE IN HUMAN OXIDIZED LDL

Authors
CARUSO D RASETTI MF DEANGELIS L GALLI G
Citation
D. Caruso et al., IDENTIFICATION OF BETA-HYDROXY-5-ALPHA-CHOLEST-6-ENE-5-HYDROPEROXIDE IN HUMAN OXIDIZED LDL, Chemistry and physics of lipids, 79(2), 1996, pp. 181-186
Citations number
28
Categorie Soggetti
Biology
Journal title
Chemistry and physics of lipids → ACNP
ISSN journal
00093084
Volume
79
Issue
2
Year of publication
1996
Pages
181 - 186
Database
ISI
SICI code
0009-3084(1996)79:2<181:IOBI>2.0.ZU;2-T
Abstract
Oxidized LDL exhibits cytotoxic activity towards endothelial cells, wh ich is thought to be mediated by the products derived also from choles terol oxidation, mainly involving the B-ring. By LC-PB-EI-MS and EI-MS /MS analysis. we have identified 3 beta-hydroxy-5 alpha-cholest-6-ene- 5-hydroperoxide among the cholesterol oxidation products in LDL incuba ted with micromolar concentrations of copper ions.