OXYGEN-TRANSPORT HEMOGLOBIN ACTIVITY IN L YMPHOID SARCOMAS

To evaluate oxygen transport function of Hb in lymphoid sarcomas, 15 p atients aged 16-63 were examined for Hb oxygen capacity, concentration s of fetal Hb and creatinin, basic ligands H+, CO2, 2,3-diphosphoglyce rate (2,3-DPG). Oxy-Hb dissociation curves were plotted. The patients' blood contained HbF in elevated quantities, whereas red cells had hig h creatinin. This emphasizes the role of hemolysis in genesis of anemi a in lymphosarcomas. 70% of the examinees retained normal Hb affinity to oxygen in vivo, in 30% this affinity exceeded the standard. Compens atory mechanism responsible for low Hb affinity to oxygen in this dise ase fails. Therefore lymphosarcoma patients with anemia need early rep lacement hemotransfusions.