USE OF A SEQUENTIAL INJECTION TECHNIQUE FOR MECHANISTIC STUDIES AND KINETIC DETERMINATION OF BROMAZEPAM COMPLEXED WITH IRON(II) IN HYDROCHLORIC-ACID

For the first time a sequential injection technique has been employed in a full kinetic investigation as well as for a kinetic procedure uti lizing the fixed-time method. The complexation reaction of bromazepam with iron(II) in hydrochloric acid was studied using spectrophotometri c detection at lambda(max) 585 nm for the product formed. A rate law w as offered, which was found to be consistent with the postulated react ion mechanism. From the observed kinetics it was found that the fixed- time method utilized at 100 s using 0.0100 mol dm(-3) iron(II) and 0.0 115 mol dm(-3) HCl had optimal conditions for the determination of bro mazepam in the range 5.0 x 10(-4)-1.5 x 10(-3) mol dm(-3). The method was found to be suitable for the determination of bromazepam in drug f ormulations.