DOES RELIEF OF CRITICAL ARTERIAL-STENOSIS ACCELERATE DISTAL ATHEROSCLEROSIS

Progression of atherosclerosis following balloon angioplasty, arterial bypass, or endarterectomy often limits long-term success of revascula rization procedures. Therefore, the authors studied the effect of sten osis and relief of stenosis on the development of distal atheroscleros is in a primate model of diet-induced atherosclerosis. Severe stenosis (78 +/- 2% diameter reduction) was produced in the midthoracic aorta in 14 cynomolgus monkeys by a constricting band. In 8 monkeys, the ste nosis was left in place for three months, after which the distal aorta was revascularized by removal of the constricting band and by balloon angioplasty of the residual stenosis. The results in this group were compared with those in 6 animals whose stenoses were not reversed and with those in 10 animals with no preexisting stenosis. All three group s received an atherogenic diet for three months with no difference in serum cholesterol (836 to 1059 mg%) during the three-month diet period . Animals with a stenosis had a significant decrease in surface athero sclerosis in the distal aorta (7 +/- 6%) compared with control animals (51 +/- 8%, P < 0.05). This was accompanied by marked reduction in mu ral cholesterol content (1.5 +/- 0.4 mcg/mm(2) vs 6.3 +/- 1.8 mcg/mm(2 ) in controls, P<0.05) and a decrease in intimal thickness (0.04 +/- 0 .02 mm vs 0.07 +/- 0.01 mm in controls, P < 0.05). After relief of the stenosis, the percent surface atherosclerosis (58 +/- 8%), mural chol esterol (5.4 +/- 1.0 mcg/mm(2)), and intimal thickness (0.09 +/- 0.01 mm) were no different from controls. Thus, severe stenosis protects th e distal vascular tree from intimal plaque formation, despite marked h ypercholesterolemia, Following reversal of a stenosis, distal plaque p rogression does not occur at an accelerated rate but instead occurs at the same rate as without a preexisting stenosis.