Ocular ischemic syndrome is caused by chronic insufficiency of the blo
od supply to the eye as a result of severe bilateral carotid artery st
enosis or occlusion. The signs of ocular ischemia syndrome include ret
inopathy (retinal microaneurysms, hemorrhages, and vein dilatation), c
ataract, iris neovascularization (rubeosis iridis), and neovascular gl
aucoma. The role of carotid endarterectomy in stabilizing and improvin
g vision in patients with ocular ischemic syndrome is controversial. T
he authors describe 2 patients with ocular ischemic syndrome and rubeo
sis who, following carotid endarterectomy, developed an intractable ri
se of intraocular pressure, which led to visual loss. The presence of
rubeosis suggests poor visual prognosis and thus should be considered
before a decision is made about carotid endarterectomy.