Sb. Colling et al., HIPPOCAMPAL SLICES FROM PRION PROTEIN NULL MICE - DISRUPTED CA2-ACTIVATED K+ CURRENTS(), Neuroscience letters, 209(1), 1996, pp. 49-52
The intrinsic properties of hippocampal CA1 pyramidal cells were exami
ned in mice lacking prion protein (PrP-null). The resting potentials,
time constants, amplitude of the medium afterhyperpolarization (AHP) a
nd spike firing accommodation did not differ from the control group. T
he PrP-null group differed in having lower input resistances, a lack o
f the late AHP and of a charybdotoxin-sensitive summated AHP. We propo
se that Ca2+-activated K+ currents, in particular I-AHP, are disrupted
in PrP-null mice.