REWIRING OF TRANSCORTICAL PROJECTIONS TO MIDDLE SUPRASYLVIAN CORTEX FOLLOWING EARLY REMOVAL OF CAT AREA-17 AND AREA-18

Retrograde tracers were injected into middle suprasylvian (MS) cortex of two groups of experimental adult cats that had incurred removal of visual areas 17 and 18 on either the day of birth (P1), or at 1 month of age (P28). Tracers were also injected into the same region of intac t and adult ablated control cats. The locations and numbers of labeled neurons in the experimental and control groups were compared. Followi ng lesions on P1, but at no other age, increased numbers of neurons pr ojected to MS cortex. Virtually all of the additional neurons were loc ated in the superficial layers of the ventral posterior suprasylvian ( VPS) cortex. These results demonstrated that (1) neurons with ipsilate ral transcortical axons have the potential to reconfigure their projec tions after early, localized cortical damage elsewhere in the cortex o f the same hemisphere; (2) this reconfiguration involves expansion of specific projections and is not a generalized capacity of all cortical neurons; (3) the expansion is modality specific; and, finally, (4) th e ability of cortical neurons to reorganize projections is limited in time. The expanded projection from vPS to MS cortex may contribute to neuronal compensations and the sparing of visually guided behaviors pr eviously demonstrated in cats with neonatal visual cortex damage, and is a testament to the latent capacities immature cerebral cortical neu rons possess to establish new projections following restricted damage to the cerebral cortex early in life.