THE EFFECTS OF HEMODIALYSIS ON DUODENAL AND GASTRIC-MUCOSAL CHANGES IN UREMIC PATIENTS

From March 1992 to July 1992 30 uremic patients (15 dialysed, 15 non-d ialysed) and 15 non-uremic patients who had dyspeptic complaints were compared in terms of gastric and duodenal diseases. Gastritis and duod enitis graded as I, II and III were not found different in three group s (p > 0.05). Although the incidence of peptic ulcer disease is very h igh in both groups of uremic patients in comparison with the controls, there was no significant difference between two uremic groups (p > 0. 05). Also the prevalence of gastritis determined histologically was no t different in dialysed and non-dialysed uremic patients (p > 0.05). T he incidence of the histologically proven gastritis was found higher i n uremic patients than in non-uremic patients (p < 0.05). But, there w ere no significant differences among the three groups with regard to t he rate of histologically proved duodenitis (p > 0.05). Gastrin levels , urea positivity, the incidence of gastritis and duodenitis and pepti c ulcers did not differ in both uremic groups. However, these values w ere found significantly high in the uremic patients when compared to n on-uremics. These findings showed serum gastrin levels H.-pylori-infec tion, gastritis and duodenal disease in the uremic patients to be high er than those of the control group. Moreover, no effect of hemodialysi s treatment on these results was observed.