COMPATIBILITY OF PROPOFOL DILUTED IN 5-PERCENT GLUCOSE WITH GLASS ANDPLASTICS (POLYPROPYLENE, POLYVINYLCHLORIDE) CONTAINERS

Authors
SAUTOUMIRANDA V LEVADOUX E GROUEIX MT CHOPINEAU J
Citation
V. Sautoumiranda et al., COMPATIBILITY OF PROPOFOL DILUTED IN 5-PERCENT GLUCOSE WITH GLASS ANDPLASTICS (POLYPROPYLENE, POLYVINYLCHLORIDE) CONTAINERS, International journal of pharmaceutics, 130(2), 1996, pp. 251-255
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
130
Issue
2
Year of publication
1996
Pages
251 - 255
Database
ISI
SICI code
0378-5173(1996)130:2<251:COPDI5>2.0.ZU;2-E
Abstract
The compatibility of propofol diluted in 5% glucose with glass, polypr opylene (PP) and polyvinylchloride (PVC) containers was evaluated afte r 30 days contact. The mixtures were exposed to several temperature an d light conditions. Propofol was assayed by high performance liquid ch romatography. Propofol interacted with PVC causing loss of 50% or more of the drug after 30 days contact. In contrast, containers made of PP or glass caused no noteworthy fall in propofol concentration. The bes t storage conditions were at +4 degrees C irrespective of the containe r material.