HIV-RELATED METABOLIC ABNORMALITIES IN THE BRAIN - DEPICTION WITH PROTON MR SPECTROSCOPY WITH SHORT ECHO TIMES

PURPOSE: To analyze brain metabolite changes in human immunodeficiency virus (HIV)-positive neurologically asymptomatic patients and patient s with acquired immunodeficiency syndrome (AIDS) dementia complex (ADC ). MATERIALS AND METHODS: Twelve ADC patients, 11 HIV-positive asympto matic patients, and 10 healthy control subjects underwent magnetic res onance (MR) imaging and proton MR spectroscopy with short echo times. Changes in N-acetyl aspartate (NAA), choline (Cho), myoinositol (MI), and creatine (Cr) were presented as ratios with Cr as the reference. R ESULTS: Statistically significant (P < .05) differences were noted. In ADC patients, all with MR findings of brain atrophy and diffuse white matter disease, NA/Cr decreased (white matter, -31.8%; gray matter, - 22.3%), MI/Cr increased (white matter, +42.5%; gray matter, +51.8%), a nd Cho/Cr increased (white matter, +20.6%; gray matter, +51.7%) compar ed with healthy control subjects. In HIV-positive asymptomatic patient s, NA/Cr decreased slightly (white matter, -6.9%; gray matter, -5.1%), MI/Cr increased slightly (white matter, +13.7%; gray matter, +10.7%), and Cho/Cr did not change. CONCLUSION: ADC has a uniform pathologic m etabolic pattern that affects NAA, MI, and Cho. Proton MR spectroscopy with short echo times helps detect early abnormalities in clinically asymptomatic patients.