Heating N-(benzotriazol-1-yl)glycine ethyl esters (2) under bar, obtai
ned by Mannich condensation of glycine ethyl esters (1) under bar, for
maldehyde and benzotriazole, in THF in the presence of excess of NaH u
nexpectedly gave diethyl trans-2,3-piperazinedicatboxylates (3) under
bar.