ACTIVATION OF CANINE MONOCYTES AND POLYMORPHONUCLEAR CELLS BY SERUM THYMIC-FACTOR (FTS) IN-VIVO

The effect of serum thymic factor (FTS) was evaluated from the immunor esponse augmented in canine monocytes and polymorphonuclear cells (PMN ) using the chemiluminescence technique. FTS did not affect the number of leukocytes and differential count of leukocytes. CL activity of th e whole blood was significantly elevated by FTS from 72 hr to 120 hr a fter administration (p<0.05), and that at 96 hr after administration w as about 3-fold higher than that before the administration. The CL res ponse of PMN was significantly elevated by FTS administration from 24 hr to 96 hr after administration (p<0.05), and that at 48 hr after adm inistration was about 7-fold higher than prior treatment. FTS also sig nificantly elevated the CL response of monocyte from 24 hr to 96 hr af ter administration (p<0.01), and the CL count of monocyte in 24 hr and 48 hr was about 100-fold higher than that before FTS administration. These findings suggested that FTS may be efficacious and useful immune -potentiator for canine monocytes and PMN.