EFFECTS OF DEPLETION OF T-CELL SUBPOPULATIONS ON THE COURSE OF INFECTION AND ANTIPARASITE DELAYED-TYPE HYPERSENSITIVITY RESPONSE IN MICE INFECTED WITH BABESIA-MICROTI AND BABESIA-RODHAINI
T. Shimada et al., EFFECTS OF DEPLETION OF T-CELL SUBPOPULATIONS ON THE COURSE OF INFECTION AND ANTIPARASITE DELAYED-TYPE HYPERSENSITIVITY RESPONSE IN MICE INFECTED WITH BABESIA-MICROTI AND BABESIA-RODHAINI, Journal of veterinary medical science, 58(4), 1996, pp. 343-347
To elucidate the role of T cell subpopulations in the protective cell-
mediated immune response at the initial phase of infection with Babesi
a microti (BM) and B. rodhaini (BR), the changes in the course of infe
ction and anti-parasite delayed type hypersensitivity (DTH) response a
fter BM or BR inoculation were investigated in Lyt-2(+) T cell- or L3T
4(+) T cell-depleted mice. Depletion of Lyt-2(+) T cells strongly enha
nced the resistance to BM infection, whereas it increased the suscepti
bility to BR infection. In contrast, depletion of L3T4(+) T cells incr
eased susceptibility to BM infection, while it enhanced resistance to
BR infection. The anti-parasite DTH response in BM-infected mice was s
ignificantly enhanced by depletion of Lyt-2(+) T cells, while signific
antly reduced by depletion of L3T4(+) T cells. No effects of depletion
of either Lyt-2(+) or L3T4(+) T cells on DTH response was observed in
BR-infected mice. From these results, it was suggested that the roles
of Lyt-2(+) and L3T4(+) T cells in the protective cell-mediated immun
e response at the initial phase of infection were different between BM
- and BR-infected mice, resulting in the difference in their course of
infection.