HYDROXYUREA MAY INCREASE THE ACTIVITY OF FLUOROURACIL PLUS FOLINIC ACID IN ADVANCED GASTROINTESTINAL CANCER - PHASE-II STUDY

Citation
F. Dicostanzo et al., HYDROXYUREA MAY INCREASE THE ACTIVITY OF FLUOROURACIL PLUS FOLINIC ACID IN ADVANCED GASTROINTESTINAL CANCER - PHASE-II STUDY, Cancer investigation, 14(3), 1996, pp. 234-238
Citations number
27
Categorie Soggetti
Oncology
Journal title
ISSN journal
07357907
Volume
14
Issue
3
Year of publication
1996
Pages
234 - 238
Database
ISI
SICI code
0735-7907(1996)14:3<234:HMITAO>2.0.ZU;2-9
Abstract
In a phase II trial, 36 patients with advanced gastrointestinal cancer were treated with: folinic acid (FA) 500 mg/m(2) in a 2-hr intravenou s (IV) infusion, 5-fluorouracil (5-FU) 600 mg/m(2) as an IV push injec tion 1 hr after FA, and hydroxyurea (HU) 35 mg/kg/day given p.o. in th ree administrations (every 8 hr) 6 hr after 5-FU. Cycles consisted of six weekly treatments for 6 weeks, followed by a 2-week rest period. T hirty-three patients were evaluable for response and 36 for toxicity; 73% had previous chemotherapy. The response rate was 30% (CR + PR), th e median duration of response was 21 weeks (range 5-36), and time to f ailure was 17 weeks (range 3-51). The response in patients previously exposed to chemotherapy was 29% and 44% in chemotherapy-naive patients . The median survival for all entered patients was 28 weeks (range 6-5 4). The most common toxicity was gastrointestinal: diarrhea 22/36 (61% ), mucositis 15/36 (42%), and nausea and vomiting 15/36 (42%); hematol ogical toxicity was mild. We conclude that HU can potentiate the activ ity of 5-FU plus FA in advanced gastrointestinal cancer; in particular , HU can restore the activity of 5-FU in patients previously exposed t o chemotherapy.