HLA CLASS-I ANTIGENS ARE POSSIBLE PROGNOSTIC FACTORS IN HEPATOCELLULAR-CARCINOMA

Citation
M. Nishibe et al., HLA CLASS-I ANTIGENS ARE POSSIBLE PROGNOSTIC FACTORS IN HEPATOCELLULAR-CARCINOMA, International journal of oncology, 8(6), 1996, pp. 1243-1247
Citations number
36
Categorie Soggetti
Oncology
ISSN journal
10196439
Volume
8
Issue
6
Year of publication
1996
Pages
1243 - 1247
Database
ISI
SICI code
1019-6439(1996)8:6<1243:HCAAPP>2.0.ZU;2-F
Abstract
Thirty patients who underwent hepatectomy for the treatment of hepatoc ellular carcinoma (HCC) were examined for expression of HLA class I an tigens on HCC cells by flow cytometry. The expression was found signif icantly lower in cases of stage IV compared with those of stage I or s tage II (p<0.05), and in cases of intrahepatic metastases compared wit h those without metastases (p<0.001). In cases of non-curative hepatec tomy, the expression of HLA class I antigens was lower compared with t hose treated by curative resection. Postoperative cumulative disease-f ree survival rates were well correlated with the expression rate of HL A class I antigens (p<0.05). Expression of HLA class I antigens on HCC may indicate low malignancy and better prognosis.