REGULATION AND EXPRESSION OF TRANSGENES IN FISH - A REVIEW

Transgenic fish, owing to a number of advantages which they offer over other species, are proving to be valuable model systems for the study of gene regulation and developmental genetics in addition to being us eful targets for the genetic manipulation of commercially important tr aits. Despite having begun only a decade ago, the production of transg enic fish has become commonplace in a number of laboratories world-wid e and considerable progress has been made. In this review, we initiall y consider the various regulatory elements and coding genes which have been used in fish, and subsequently discuss and compare both the tran sient and long-term fate and expression patterns of injected DNA seque nces in the context of the different factors which are likely to have an effect on the expression of transgenes.