DIRECT AND INDIRECT RADICAL DENITRATIONS OF INTERMEDIATES IN THE SYNTHESIS OF SORGOLACTONE AND ITS NUCLEAR ANALOGS

Authors
MIKLO K JASZBERENYI JC KADAS I ARVAI G TOKE L
Citation
K. Miklo et al., DIRECT AND INDIRECT RADICAL DENITRATIONS OF INTERMEDIATES IN THE SYNTHESIS OF SORGOLACTONE AND ITS NUCLEAR ANALOGS, Tetrahedron letters, 37(20), 1996, pp. 3491-3494
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
20
Year of publication
1996
Pages
3491 - 3494
Database
ISI
SICI code
0040-4039(1996)37:20<3491:DAIRDO>2.0.ZU;2-L
Abstract
Denitration of various important intermediates in the synthesis of sor golactone and its analogs using radical chemistry on nitroketones or o n the derived isocyanides is described The nitro group is needed for t he first step of the annellation process, the Michael addition of subs tituted nitroalkanes to cyclopentenones. Then it can be removed direct ly or after reduction to the amine or via the ketone obtained by the N ef-reaction. Copyright (C) 1996 Elsevier Science Ltd