DISPACAMIDES, ANTIHISTAMINE ALKALOIDS FROM CARIBBEAN AGELAS SPONGES

Authors
CAFIERI F FATTORUSSO E MANGONI A TAGLIALATELASCAFATI O
Citation
F. Cafieri et al., DISPACAMIDES, ANTIHISTAMINE ALKALOIDS FROM CARIBBEAN AGELAS SPONGES, Tetrahedron letters, 37(20), 1996, pp. 3587-3590
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
20
Year of publication
1996
Pages
3587 - 3590
Database
ISI
SICI code
0040-4039(1996)37:20<3587:DAAFCA>2.0.ZU;2-U
Abstract
Dispacamide 1 and its monobromo derivative 2, are novel bromopyrrole a lkaloids containing an aminoimidazolone moiety. They were isolated fro m four Caribbean Agelas sponges (A. conifera, A. longissima, A. clathr odes, A. dispar), and their structures elucidated on the basis of spec troscopic data. Compounds 1 and 2 exhibit remarkably selective antihis tamine activity, tested on the guinea pig ileum. Copyright (C) 1996 Pu blished by Elsevier Science Ltd