IN-VIVO DIFFUSION SPECTROSCOPY - AN OVERVIEW

This review describes in vivo NMR measurements of metabolite diffusion . NMR spectroscopy can employ a variety of endogeneous marker molecule s to obtain information on various aspects of in vivo biochemistry and biophysics from the diffusion characteristics of these markers. NMR-b ased metabolite diffusion data give an insight into the physico-chemic al properties of the intracellular compartment and of changes therein in relation to development and pathology. Recent applications have pro ven that in vivo diffusion spectroscopy provides exciting opportunitie s to both fundamental and applied research.