ENZYMATIC LABORATORY-SCALE PRODUCTION OF HOMOCHIRAL (R)-3-FLUOROLACTIC ACID METHYL-ESTER VIA ENANTIOSPECIFIC REDUCTION OF SODIUM FLUOROPYRUVATE CATALYZED BY RABBIT MUSCLE L-LACTATE DEHYDROGENASE (L-LDH)

Authors
GONCALVES LPB ANTUNES OAC PINTO GF OESTREICHER EG
Citation
Lpb. Goncalves et al., ENZYMATIC LABORATORY-SCALE PRODUCTION OF HOMOCHIRAL (R)-3-FLUOROLACTIC ACID METHYL-ESTER VIA ENANTIOSPECIFIC REDUCTION OF SODIUM FLUOROPYRUVATE CATALYZED BY RABBIT MUSCLE L-LACTATE DEHYDROGENASE (L-LDH), Tetrahedron : asymmetry, 7(5), 1996, pp. 1237-1240
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
5
Year of publication
1996
Pages
1237 - 1240
Database
ISI
SICI code
0957-4166(1996)7:5<1237:ELPOH(>2.0.ZU;2-4
Abstract
In the present work a simple laboratory procedure for the synthesis of (R)3-Fluorolactic Methyl Ester(1) is described A coupled enzymatic sy stem formed by rabbit muscle L-lactate dehydrogenase (L-LDH), horse li ver alcohol dehydrogenase (HLADH), fluoropyruvic acid sodium salt, NAD (+) and cis-1,2-bis(hydroxymethyl)cyclohexane were found to be very ef fective for production of(1) in 80% overall yield and ee > 99%. Copyri ght (C) 1996 Elsevier Science Ltd