SYNTHESIS OF ARYL 2-BENZOFURANYL AND ARYL 2-INDOLYL CARBINOLS OF HIGHENANTIOMERIC PURITY VIA PALLADIUM-CATALYZED HETEROANNULATION OF CHIRAL ARYLPROPARGYLIC ALCOHOLS

Authors
BOTTA M SUMMA V CORELLI F DIPIETRO G LOMBARDI P
Citation
M. Botta et al., SYNTHESIS OF ARYL 2-BENZOFURANYL AND ARYL 2-INDOLYL CARBINOLS OF HIGHENANTIOMERIC PURITY VIA PALLADIUM-CATALYZED HETEROANNULATION OF CHIRAL ARYLPROPARGYLIC ALCOHOLS, Tetrahedron : asymmetry, 7(5), 1996, pp. 1263-1266
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
5
Year of publication
1996
Pages
1263 - 1266
Database
ISI
SICI code
0957-4166(1996)7:5<1263:SOA2AA>2.0.ZU;2-V
Abstract
2-Iodophenol and 2-iodo-N-mesylaniline have been reacted with alpha-ar ylpropargylic alcohols of high enantiomeric purity under transition-me tal catalysis leading to aryl 2-benzofuranyl and aryl 2-indolyl carbin ols in good yield and high enantiomeric excess, thus constituting the first enantiospecific synthesis of these important classes of compound s. Copyright (C) 1996 Elsevier Science Ltd