SYNTHESIS AND APPLICATION OF NEW CHIRAL LIGANDS FOR THE ASYMMETRIC BORANE REDUCTION OF PROCHIRAL KETONES

Authors
HULST R HERES H PEPER NCMW KELLOGG RM
Citation
R. Hulst et al., SYNTHESIS AND APPLICATION OF NEW CHIRAL LIGANDS FOR THE ASYMMETRIC BORANE REDUCTION OF PROCHIRAL KETONES, Tetrahedron : asymmetry, 7(5), 1996, pp. 1373-1384
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
5
Year of publication
1996
Pages
1373 - 1384
Database
ISI
SICI code
0957-4166(1996)7:5<1373:SAAONC>2.0.ZU;2-L
Abstract
Two chiral nonracemic gamma-amino alcohols, ephedrine thiol and the co rresponding (thio)-phosphoramidates and (thio)-phosphinamides have bee n examined as catalysts for the reduction of propiophenone by various boranes. Up to 95% e.e. can be obtained with the phosphorus derivative s. Copyright (C) 1996 Elsevier Science Ltd