STRIATAL [C-11] N-METHYL-SPIPERONE BINDING IN PATIENTS WITH FOCAL DYSTONIA (TORTICOLLIS) USING POSITRON EMISSION TOMOGRAPHY

Authors
LEENDERS K HARTVIG P FORSGREN L HOLMGREN G ALMAY B ECKERNAS SA LUNDQVIST H LANGSTROM B
Citation
K. Leenders et al., STRIATAL [C-11] N-METHYL-SPIPERONE BINDING IN PATIENTS WITH FOCAL DYSTONIA (TORTICOLLIS) USING POSITRON EMISSION TOMOGRAPHY, Journal of neural transmission. Parkinson's disease and dementia section, 5(2), 1993, pp. 79-87
Citations number
31
Categorie Soggetti
Clinical Neurology
Journal title
Journal of neural transmission. Parkinson's disease and dementia section → ACNP
ISSN journal
09363076
Volume
5
Issue
2
Year of publication
1993
Pages
79 - 87
Database
ISI
SICI code
0936-3076(1993)5:2<79:S[NBIP>2.0.ZU;2-#
Abstract
Specific binding of [C-11]-N-methyl-spiperone to striatal dopamine D2 receptors was assessed using positron emission tomography (PET) in 6 p atients with adult-onset focal dystonia (predominantly spasmodic torti collis) and in 5 healthy subjects. No significant difference in averag e specific striatal tracer uptake between patients and healthy subject s was found. However, in the 5 patients showing lateralisation of clin ical signs a trend to higher striatal tracer uptake in the contralater al hemisphere was observed.