STIMULATION OF DOPAMINE BIOSYNTHESIS IN CULTURED PC-12 PHEOCHROMOCYTOMA CELLS BY THE COENZYME NICOTINAMIDE ADENINEDINUCLEOTIDE (NADH)

Authors
VRECKO K BIRKMAYER JGD KRAINZ J
Citation
K. Vrecko et al., STIMULATION OF DOPAMINE BIOSYNTHESIS IN CULTURED PC-12 PHEOCHROMOCYTOMA CELLS BY THE COENZYME NICOTINAMIDE ADENINEDINUCLEOTIDE (NADH), Journal of neural transmission. Parkinson's disease and dementia section, 5(2), 1993, pp. 147-156
Citations number
24
Categorie Soggetti
Clinical Neurology
Journal title
Journal of neural transmission. Parkinson's disease and dementia section → ACNP
ISSN journal
09363076
Volume
5
Issue
2
Year of publication
1993
Pages
147 - 156
Database
ISI
SICI code
0936-3076(1993)5:2<147:SODBIC>2.0.ZU;2-5
Abstract
The activity of the tyrosine hydroxylase. the enzyme which is diminish ed in the brains of Parkinson patients, has been measured in cultured PC 12 rat phaeochromocytoma cells. In the same way dopamine content in the medium after incubating these cells with or without NADH was assa yed. The experiment shows that NADH is able to increase the activity o f the tyrosine hydroxylase and dopamine - production in PC 12 cells up to 6 times. The results provide evidence that NADH is able to stimula te dopamine - biosynthesis directly.