THE EFFECT OF ORENGEDOKUTO ON EXPERIMENTALLY-INFLAMED RATS

The inhibitory effect of Orenge dokuto on lipid peroxide and sialidase was investigated using rats affected with carrageenin cotton pellet-i nduced granuloma and adjuvant arthritis. As a result, in the case of r ats with carrageenin cotton pellet-induced granuloma, a significant in hibitory effect on granuloma formation was observed in the Orengedokut o treated rats (150 mg/kg/day) which showed a decrease in serum lipid peroxide (p<0.001) and an increase in acid soluble glycoprotein (p<0.0 01). In the case of adjuvant-induced arthritic rats, however, the cond ition of the arthritis was not improved at all, and was even aggravate d in spite of the decrease in serum lipid peroxide.