RISK ASSESSMENT FOR NEUROBEHAVIORAL TOXICITY - SGOMSEC JOINT REPORT

Behavioral end points for neurotoxicity risk assessment have been deve loped and examined over the past three decades. They are now ready to move from simple qualitative guidelines, such as exemplified by refere nce doses, to more quantitative models, such as benchmark doses, based on dose-response information. Risk assessors, confronted by a wider a rray of methodologies and data than in the past, should be offered gui dance in interpretation because now they have to deal with unaccustome d questions and problems. These include reversibility, susceptible pop ulations, multiple end points, and the details of dose-response and do se-effect distributions.