This article reports the results of an animal study designed to evalua
te the usefulness of butyl 2-cyanoacrylate (Histoacryl) in blepharopla
sty skin closure. Bilateral upper and lower lid blepharoplasty skin in
cisions were made on seven pigs. We compared the wounds closed with 6.
0 nylon to those closed with Histoacryl at 1, 2, 4, and 9 weeks postop
eratively. The tensile strength of the ''glued'' incisions was signifi
cantly greater than that of the sutured incisions only at the 9-week p
ostoperative interval (p < 0.05). There was no significant difference
in bond strength, however, between the two methods at 1, 2 and 4 weeks
postoperatively. Histopathologic analyses of sutured and glued wounds
were compared at the same designated postoperative periods. No delete
rious effects were found in the overall healing of the cutaneous wound
s closed with Histoacryl.