P450 2E1 EXPRESSION IN LIVER, KIDNEY, AND LUNG OF RATS TREATED WITH SINGLE OR COMBINED INDUCERS

Authors
GOASDUFF T BELLEC G AMET Y DREANO Y MENEZ JF BERTHOU F
Citation
T. Goasduff et al., P450 2E1 EXPRESSION IN LIVER, KIDNEY, AND LUNG OF RATS TREATED WITH SINGLE OR COMBINED INDUCERS, Alcohol, 13(3), 1996, pp. 301-308
Citations number
40
Categorie Soggetti
Substance Abuse","Pharmacology & Pharmacy",Toxicology
Journal title
Alcohol → ACNP
ISSN journal
07418329
Volume
13
Issue
3
Year of publication
1996
Pages
301 - 308
Database
ISI
SICI code
0741-8329(1996)13:3<301:P2EILK>2.0.ZU;2-6
Abstract
Ethanol consumption combined with smoking increases the risk of cancer in many tissues. Such a mechanism implies the involvement of cytochro me P450 alcohol (CYP2E1), which is regulated by numerous xenobiotics. The combination of P450 2E1 inducers (acetone or pyridine) and 3-methy lcholanthrene during rat treatment was shown to decrease the liver P45 0 2E1 content while it enhanced its expression in kidney. It is sugges ted that this differential tissue response helps explain the organotro py of nitrosamine carcinogenicity.