KINETICS OF SIALYLATION OF NEISSERIA-GONO RRHOEAE BY C-14-RADIO-LABELED CYTIDINE 5'MONOPHOSPHO-N-ACETYL NEURAMINIC ACID

Authors
GOLDNER M EMOND JP GERMANI E LAUNAY JM DUBLANCHET A
Citation
M. Goldner et al., KINETICS OF SIALYLATION OF NEISSERIA-GONO RRHOEAE BY C-14-RADIO-LABELED CYTIDINE 5'MONOPHOSPHO-N-ACETYL NEURAMINIC ACID, Pathologie et biologie, 44(4), 1996, pp. 249-253
Citations number
24
Categorie Soggetti
Pathology
Journal title
Pathologie et biologie → ACNP
ISSN journal
03698114
Volume
44
Issue
4
Year of publication
1996
Pages
249 - 253
Database
ISI
SICI code
0369-8114(1996)44:4<249:KOSONR>2.0.ZU;2-4
Abstract
Neisseria gonorrhoeae (Strain A) induces a sialyl-transferase when tre ated with a very low concentration of cytidine 5'monophospho-N-acetyl neuraminic acid, 2 x 10(-3) nmol.ml(-1), a concentration which is insu fficient to produce an adequate resistance to human serum complement. The sialyl-transferase activity was detected by measurement of fixed C -14 radio-labeled sialyl groups. Without this stimulation, there was p ractically no transfer of sialyl groups. The gonococcal sialyl-transfe rase could be considered inducible.