SYNTHESIS OF PHOSPHORUS-CONTAINING AMINO-ACID-ANALOGS AS INHIBITORS OF NITRIC-OXIDE SYNTHASE

Authors
COWART M KOWALUK EA KOHLHAAS KL ALEXANDER KM KERWIN JF
Citation
M. Cowart et al., SYNTHESIS OF PHOSPHORUS-CONTAINING AMINO-ACID-ANALOGS AS INHIBITORS OF NITRIC-OXIDE SYNTHASE, Bioorganic & medicinal chemistry letters, 6(9), 1996, pp. 999-1002
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
9
Year of publication
1996
Pages
999 - 1002
Database
ISI
SICI code
0960-894X(1996)6:9<999:SOPAAI>2.0.ZU;2-M
Abstract
Two series of alpha-amino phosphonic and alpha-amino phosphinic analog s of arginine were prepared and tested as inhibitors of nitric oxide s ynthase (NOS). Two of the analogs were found to possess inhibitory act ivity for the neuronal isoform of NOS. (C) 1996 Elsevier Science Ltd.