SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS .2. MODIFICATION OF THE PHENYL RING - THE POTENTIATING EFFECT OF FLUORINE SUBSTITUTION ON IN-VIVO ACTIVITY

Various electron-withdrawing groups were incorporated into the meta po sition of tropone-substituted 3-phenyl-2-oxazolidinones and their infl uence on antibacterial activity examined. Consideration of in vitro an d in vivo test results indicated that one or two fluorine atoms flanki ng the para tropone appendage is the optimum arrangement for these com pounds. Synthetic routes to enantiomerically enriched analogues are re ported. (C) 1996 Elsevier Science Ltd.