TETRAZOLE NK1 RECEPTOR ANTAGONISTS - THE IDENTIFICATION OF AN EXCEPTIONALLY POTENT ORALLY-ACTIVE ANTIEMETIC COMPOUND

Authors
ARMOUR DR CHUNG KML CONGREVE M EVANS B GUNTRIP S HUBBARD T KAY C MIDDLEMISS D MORDAUNT JE PEGG NA VINADER MV WARD P WATSON SP
Citation
Dr. Armour et al., TETRAZOLE NK1 RECEPTOR ANTAGONISTS - THE IDENTIFICATION OF AN EXCEPTIONALLY POTENT ORALLY-ACTIVE ANTIEMETIC COMPOUND, Bioorganic & medicinal chemistry letters, 6(9), 1996, pp. 1015-1020
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
9
Year of publication
1996
Pages
1015 - 1020
Database
ISI
SICI code
0960-894X(1996)6:9<1015:TNRA-T>2.0.ZU;2-5
Abstract
The medicinal chemistry strategy is described which led to the identif ication of GR205171, an orally active non-peptide neurokinin-1 recepto r antagonist that is the most potent broad-spectrum antiemetic agent r eported to date. (C) 1996 Elsevier Science Ltd.