DESIGN, SYNTHESIS, AND ANTITUMOR-ACTIVITY OF BICYCLIC AND ISOMERIC ANALOGS OF ILLUDIN-M

Authors
KINDER FR WANG RM BAUTA WE BAIR KW
Citation
Fr. Kinder et al., DESIGN, SYNTHESIS, AND ANTITUMOR-ACTIVITY OF BICYCLIC AND ISOMERIC ANALOGS OF ILLUDIN-M, Bioorganic & medicinal chemistry letters, 6(9), 1996, pp. 1029-1034
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
9
Year of publication
1996
Pages
1029 - 1034
Database
ISI
SICI code
0960-894X(1996)6:9<1029:DSAAOB>2.0.ZU;2-8
Abstract
Novel bicyclic and isomeric analogues of the cytotoxic sesquiterpine i lludin M were prepared using 1,3-dipolar cycloaddition reactions. Near ly every analogue investigated demonstrated low mu M IC50 values when tested in a panel of four human tumor cell lines. (C) 1996 Elsevier Sc ience Ltd.