GENETICALLY DIVERSE PIG MODELS FOR NEONATAL CHOLESTEROL NUTRITION - AREVIEW (VOL 16, PG 707, 1996)

Lipid metabolism and cholesterol homeostasis in swine are reviewed in relation to the use of the pig as a model for studying neonatal choles terol nutrition. Several genetically unique pig populations used in ca rdiovascular and obesity research are described. Recent work with two specific genetically selected populations (obese and lean and high and low plasma cholesterol) is summarized. The results illustrate that di etary cholesterol during the neonatal period modulates central nervous system development and atherogenesis in some genetically distinct pop ulations of swine. Implications for the role of dietary cholesterol in human infant nutrition are discussed.