IMMUNE RECOVERY AFTER AUTOLOGOUS OR RHG-CSF PRIMED PBSC TRANSPLANTATION

We performed a prospective study in 17 consecutive patients following autologous bone marrow (BM) or rhG-CSF primed peripheral blood stem ce ll (PBSC) transplantation, with the objective of comparing immune reco very between both procedures and to evaluate results in rhG-CSF mobili zed peripheral blood stem cell transplantation (PBSCT). Kinetics of im mune reconstitution showed differences, with a faster recovery of CD3( +) and CD8(+) T cells, and a more rapid and sustained recovery of CD8( +/-)/CD56(+) natural killer (NK) cells in the PBCSCT group. Autologous bone marrow transplantation (ABMT) was associated with a improved rec onstitution of the CD19(+)/CD5(+/-) subpopulation. Moreover, rhG-CSF m obilized PBSCT generated a greater recovery of CD8(+/-)/CD56(+) cells than previous data concerning transplantation with peripheral blood (P B) progenitors collected after myelosuppressive chemotherapy or myelos uppressive therapy plus rhG-CSF. Our results show differences in the r ate and pattern of B and T lymphocytes reconstitution after ABMT and P BSCT. Additionally, we state an enhancement of CD56(+) cells in patien ts undergoing PBSCT mobilized solely using rhG-CSF.