HEMODYNAMIC-CHANGES DURING HIGH-FREQUENCY OSCILLATION FOR RESPIRATORY-DISTRESS SYNDROME

In a crossover trial left ventricular output (LVO), cerebral blood flo w velocity (CBFV), and resistance index (RI) of the anterior cerebral artery were compared using Doppler ultrasonography, in eight preterm i nfants with respiratory distress syndrome (RDS) during conventional me chanical ventilation and high frequency oscillation. LVO was 14% to 18 % lower with high frequency oscillation. There were no significant cha nges in CBFV. On the first day of life there was a trend towards lower RI on high frequency oscillation; the fall in LVO on high frequency o scillation was not related to lung hyperinflation. Changes in ventilat ion type (from conventional mechanical ventilation to high frequency o scillation, or vice versa) can induce significant LVO changes in prete rm infants with RDS.