THE CHROMATOGRAPHIC BEHAVIOR OF ARYLTHIOA CETATES AND THEIR OXIDATION-PRODUCTS .2. IN REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

The reversed-phase high performance liquid chromatographic behaviour o f arylthioacetates and their oxidation products has been studied by us ing ODS as stationary phase and methanol-water as mobile phase, The re lationship between the retention characteristics and the molecular str ucture of these compounds was investigated. Results showed that: (1) T he k' values increase with the increase of alkyl chain length (k'(-CH, CH3,2)> k'(-CH3)); (2) The k' values decrease with the number of oxyge n in polar functional groups increasing (k'(-s-)>k'(-so-)>k'(-so2-)); (3) the k' values increase evidently when chlorine exists in benzene r ing; (4) The effect of nitro-group in benzene ring on k' values is dep endent upon the number and substituting position of polar groups.