RENAL AND METABOLIC EFFECTS OF RECOMBINAN T HUMAN GROWTH-HORMONE (RHGH) DURING CHRONIC-RENAL-FAILURE

We report the renal and metabolic effects of a 40 day administration o f recombinant human growth hormone in a 31 years old diabetic and GH-d eficient patient who underwent a kidney and pancreas transplantation. The data show an increase in glomerular filtration rate, tubular reabs orption of phosphate, and plasma hemoglobin level. Anabolism is sugges ted from a decrease in serum urea nitrogen and an increase in muscle m ass (increase in plasma creatinine). These positive effects might be p artly explained by an overcome of endogenous growth hormone resistance when administering pharmacological doses of recombinant growth hormon e.