LOSS OF HETEROZYGOSITY IN THE VNTR REGION OF INTRON-1 OF P53 IN 2 RETINOBLASTOMA CASES

Authors
EMRE S SUNGUR A BILGIC S BUYUKPAMUKCU M GUNALP I OZGUC M
Citation
S. Emre et al., LOSS OF HETEROZYGOSITY IN THE VNTR REGION OF INTRON-1 OF P53 IN 2 RETINOBLASTOMA CASES, Pediatric hematology and oncology, 13(3), 1996, pp. 253-256
Citations number
14
Categorie Soggetti
Pediatrics,Oncology,Hematology
Journal title
Pediatric hematology and oncology → ACNP
ISSN journal
08880018
Volume
13
Issue
3
Year of publication
1996
Pages
253 - 256
Database
ISI
SICI code
0888-0018(1996)13:3<253:LOHITV>2.0.ZU;2-Z
Abstract
Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase ch ain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumours. Heterozygosity was found at this region in 5 of 10 cases. Two pathology paraffin block samples showed loss of heterozygosity.