BREAST METASTASIS IN ADOLESCENTS WITH ALVEOLAR RHABDOMYOSARCOMA OF THE EXTREMITIES - REPORT OF 2 CASES

We describe two adolescent girls with alveolar rhabdomyosarcoma arisin g from extremities who developed bilateral breast metastasis In their clinical course. In both cases, there was widespread systemic disease at initial presentation. Although complete remission was achieved on t he 25th week post-chemotherapy initiation, the first patient developed breast metastasis in addition to systemic recurrence on the 44th week and expired. For the second patient, breast metastasis was noted in a ddition to systemic disease at initial presentation. Aggressive chemot herapy with autologous transplant and radiotherapy were given in addit ion to bilateral subcutaneous total mastectomy. The patient remained i n complete remission 3 months post-therapy. We postulate that adolesce nt females with alveolar rhabdomyosarcoma of the extremities have a hi gh risk of developing breast metastasis In the pubertal period, and ag gressive multidisciplinary treatment is indicated.