The U.S. Human Genome Project (HGP) is a federally funded effort to pr
oduce a detailed genetic and physical map of all human chromosomes. Be
cause of their central role in reproduction and caregiving, women are
likely to be affected differently, and more significantly, by the info
rmation the HGP generates. It is important to identify inequities that
may emerge from gender differences and to consider ways in which they
may be avoided, reduced, or overcome. Although this type of analysis
is one of the goals of the Ethical, Legal, and Social Issues Program o
f the National Center for Human Genome Research, few studies have focu
sed explicitly on the impact of the HGP on women. This article describ
es the potential impact of the ''new genetics'' on women. Identificati
on of gender differences as they affect both research and clinical pra
ctice and the psychosocial, legal, and ethical implications of the HGP
should evoke and inform public discussion and policies that may be ge
nerated by these issues.