H. Fusamoto et al., ENDOSCOPIC APPEARANCES OF HEMORRHAGIC PEPTIC-ULCERS AND EFFICACY OF H-2-RECEPTOR ANTAGONISTS, Hepato-gastroenterology, 43(7), 1996, pp. 169-173
Background/Aim: In this retrospective study, we compared the effects o
f histamine H-2-receptor antagonists to those of antacids and antichol
inergics in. patients with hemorrhagic ulcers with various endoscopic
appearances of bleeding.Patients and Methods: Patients with hemorrhagi
c ulcers (n=376) were examined by emergency endoscopy and were treated
with 1) antacids and anticholinergic drugs or 2) H-2-receptor antagon
ists. Results: In ulcer patients with oozing or fresh red coagulation
H-2-receptor antagonists ceased further hemorrhage more effectively (6
5.9% of the cases) than antacids and anticholinergic drugs (46.7%). In
patients with projectile bleeding, both of the treatments failed to s
top hemorrhage. There were no significant differences in favorable out
come in the patients only with old black coagulation, between antacid
and anticholinergic drugs-treated group and H-2-receptor antagonists-t
reated group (94.4% and 93.8%, respectively). Conclusions: The results
suggest that H-2-receptor antagonists are more effective than antacid
s and anticholinergic drugs in patents with peptic ulcer with fresh co
agulation or oozing, but not with projectile bleeding or old black coa
gulation The results also indicate that endoscopic appearances of pept
ic ulcer bleeding are good predictors for the effects of medication.