DELUSIONAL DEPRESSION IN PATIENTS WITH PR OGRESSIVE PARALYSIS, DEFICIENCY OF VITAMIN-B12 AND SUBCLINICAL HYPERTHYROIDISM - A CASE-REPORT

Affective disturbances or paranoid syndromes are very well known in di fferent somatic diseases. A depressive syndrome with psychotic feature s as psychopathological symptoms of a neurolues is described rarely in the literature. We report about a male depressed inpatient, 64 years old, admitted because of delusional depression with hypochondrical ide as and a periodical course. In the laboratory test lues was positive, vitamin B12 showed a borderline deficiency, a subclinical hyperthyroid ism was found. The inpatient received treatment with antidepressants a nd antipsychotics, penicilline intravenous and a substitution of vitam in B12 which led to a complete improvement of delusional symptomes. At the end of treatment an organic psychosyndrome with mild depressive m ood was seen. Course of therapy, treatment complications and clinical picture are discussed as well as possible relations in the sense of co morbidity and etiology between an organic infective disease of the CNS and depressive episodes.